Mouse models challenged
نویسندگان
چکیده
منابع مشابه
I-54: New Models for Human and Mouse Genetic
The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...
متن کاملMouse models and mouse supermodels
report that Hedgehog (HH) signalling is essential for growth of human colon carcinoma (CC) (Varnat et al, 2009). In the accompanying Closeup article (Gulino et al, 2009) state that while participation of the HH pathway in CC has been controversial because of conflicting and contradictory data (Varnat et al, 2009) resolve this controversy. Although I agree the study resolves the controversy, it ...
متن کاملMouse models and mouse supermodels
report that Hedgehog (HH) signalling is essential for growth of human colon carcinoma (CC) (Varnat et al, 2009). In the accompanying Closeup article (Gulino et al, 2009) state that while participation of the HH pathway in CC has been controversial because of conflicting and contradictory data (Varnat et al, 2009) resolve this controversy. Although I agree the study resolves the controversy, it ...
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The A- and B-type lamins are nuclear intermediate filament proteins in eukaryotic cells with a broad range of functions, including the organization of nuclear architecture and interaction with proteins in many cellular functions. Over 180 disease-causing mutations, termed 'laminopathies,' have been mapped throughout LMNA, the gene for A-type lamins in humans. Laminopathies can range from muscul...
متن کاملMouse models of medulloblastoma
Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2013
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.2429